Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): T Cell, Cell Culture
SUBMITTER: Yagnesh Umrania
LAB HEAD: Paul Lehner
PROVIDER: PXD002934 | Pride | 2015-11-09
REPOSITORIES: Pride
Matheson Nicholas J NJ Sumner Jonathan J Wals Kim K Rapiteanu Radu R Weekes Michael P MP Vigan Raphael R Weinelt Julia J Schindler Michael M Antrobus Robin R Costa Ana S H AS Frezza Christian C Clish Clary B CB Neil Stuart J D SJ Lehner Paul J PJ
Cell host & microbe 20151001 4
Critical cell surface immunoreceptors downregulated during HIV infection have previously been identified using non-systematic, candidate approaches. To gain a comprehensive, unbiased overview of how HIV infection remodels the T cell surface, we took a distinct, systems-level, quantitative proteomic approach. >100 plasma membrane proteins, many without characterized immune functions, were downregulated during HIV infection. Host factors targeted by the viral accessory proteins Vpu or Nef included ...[more]