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Liraglutide effect on STZ Mouse Kidney with diabetic nephropathy

ABSTRACT: The effect of liraglutide on the kidney proteome in the STZ mouse model compared to healthy and STZ diabetic control groups.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Kidney

DISEASE(S): Type 2 Diabetes Mellitus,Type 1 Diabetes Mellitus,Diabetic Nephropathy

SUBMITTER: Leena Liljedahl

LAB HEAD: Peter James

PROVIDER: PXD003007 | Pride | 2019-01-18

REPOSITORIES: Pride

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The impact of the glucagon-like peptide 1 receptor agonist liraglutide on the streptozotocin-induced diabetic mouse kidney proteome.

Liljedahl Leena L Pedersen Maiken H MH McGuire James N JN James Peter P

Physiological reports 20190201 4

In diabetes mellitus (DM), the kidneys are exposed to increased levels of hyperglycemia-induced oxidative stress. Elevated amounts of reactive oxygen species (ROS) are believed to provoke ultrastructural changes in kidney tissue and can eventually result in DM late complications such as diabetic nephropathy. While it is reported that glucagon-like peptide 1 receptors (GLP-1R) are present in the kidney vasculature, the effects of GLP-1 on the kidney proteome in DM is not well described. Thus, we ...[more]

PMID: 30806030

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