Dataset Information

AD+CVD temporal lobe proteome - Gender differences in white matter pathology and mitochondrial dysfunction in Alzheimer's disease with cerebrovascular disease

ABSTRACT: Unbiased discovery-driven quantitative proteomics was performed to profile expression changes and degenerative modifications in the temporal lobe proteome (BA21) of AD+CVD patients compared to normal age-matched controls.

INSTRUMENT(S): QSTAR

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Dementia

SUBMITTER: Xavier Gallart Palau

LAB HEAD: Siu Kwan Sze

PROVIDER: PXD003027 | Pride | 2016-04-07

REPOSITORIES: Pride

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Publications

Gender differences in white matter pathology and mitochondrial dysfunction in Alzheimer's disease with cerebrovascular disease.

Gallart-Palau Xavier X Lee Benjamin S T BS Adav Sunil S SS Qian Jingru J Serra Aida A Park Jung Eun JE Lai Mitchell K P MK Chen Christopher P CP Kalaria Raj N RN Sze Siu Kwan SK

Molecular brain 20160317

<h4>Background</h4>Dementia risk in women is higher than in men, but the molecular neuropathology of this gender difference remains poorly defined. In this study, we used unbiased, discovery-driven quantitative proteomics to assess the molecular basis of gender influences on risk of Alzheimer's disease with cerebrovascular disease (AD + CVD).<h4>Results</h4>We detected modulation of several redox proteins in the temporal lobe of AD + CVD subjects, and we observed sex-specific alterations in the ...[more]

PMID: 26983404

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Dataset Information

AD+CVD temporal lobe proteome - Gender differences in white matter pathology and mitochondrial dysfunction in Alzheimer's disease with cerebrovascular disease

Publications

Gender differences in white matter pathology and mitochondrial dysfunction in Alzheimer's disease with cerebrovascular disease.

Similar Datasets

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