Identification and Quantitative Analysis of Cellular Proteins Affected by Treatment with Withaferin A using a SILAC-based Proteomics Approach

ABSTRACT: Withaferin A (WA) is a major bioactive compound isolated from the medicinal plant Withania somnifera Dunal, also known as ‘‘Ashwagandha’’. A number of published reports suggest various uses for WA including its function as an anti-inflammatory and anti-angiogenic drug molecule. The effects of WA at the molecular level in a cellular environment are not well understood. Knowledge of the molecular mechanism of action of WA could enhance its therapeutic value and may reveal novel pathways it may modulate.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture, Microglial Cell

SUBMITTER: Umesh Jinwal  

LAB HEAD: Umesh Jinwal

PROVIDER: PXD003032 | Pride | 2015-11-10

REPOSITORIES: Pride