Dataset Information
Serpinb1 as a novel beta cell growth factor
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Pancreatic Islet Cancer Cell
SUBMITTER: 
Matthew Monroe
LAB HEAD: Weijun Qian
PROVIDER: PXD003182 | Pride | 2016-01-21
REPOSITORIES: Pride
Publications
SerpinB1 Promotes Pancreatic β Cell Proliferation.
Cell metabolism 20151215 1
Although compensatory islet hyperplasia in response to insulin resistance is a recognized feature in diabetes, the factor(s) that promote β cell proliferation have been elusive. We previously reported that the liver is a source for such factors in the liver insulin receptor knockout (LIRKO) mouse, an insulin resistance model that manifests islet hyperplasia. Using proteomics we show that serpinB1, a protease inhibitor, which is abundant in the hepatocyte secretome and sera derived from LIRKO mic ...[more]