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N-glyco STZ mouse kidney - N-glycosylation proteome enrichment analysis in kidney reveals differences between diabetic mouse models

ABSTRACT: N-glycosylated proteome of STZ diabetic mice with diabetic nephropathy

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus

TISSUE(S): Kidney

DISEASE(S): Type 2 Diabetes Mellitus,Type 1 Diabetes Mellitus,Diabetic Nephropathy

SUBMITTER: Leena Liljedahl

LAB HEAD: Leena Liljedahl

PROVIDER: PXD003196 | Pride | 2016-12-13

REPOSITORIES: Pride

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N-glycosylation proteome enrichment analysis in kidney reveals differences between diabetic mouse models.

Liljedahl Leena L Pedersen Maiken Højgaard MH Norlin Jenny J McGuire James N JN James Peter P

Clinical proteomics 20161015

<h4>Background</h4>Diabetic nephropathy (DN) is a late complication in both type 1 diabetes mellitus (T1DM) and T2DM. Already at an early stage of DN morphological changes occur at the cell surface and in the extracellular matrix where the majority of the proteins carry N-linked glycosylations. These glycosylated proteins are highly important in cell adhesion and cell-matrix processes but not much is known about how they change in DN or whether the distinct etiology of T1DM and T2DM could have a ...[more]

PMID: 27757071

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