Dataset Information
Proteomic characterization of MEIOC interactants: part 2
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Suspension Culture, Early Embryonic Cell
SUBMITTER: 
Jean ARMENGAUD
LAB HEAD: Jean Armengaud
PROVIDER: PXD003200 | Pride | 2015-11-25
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| F100745_IP-HEK-G15.mzid.gz | Mzid | |||
| F100745_IP-HEK-G15.pride.mztab.gz | Mztab | |||
| F100747_IP-HEK-PCIG.mzid.gz | Mzid | |||
| F100747_IP-HEK-PCIG.pride.mztab.gz | Mztab | |||
| IP-HEK-G15_1.RAW | Raw |
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Publications
Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts.
Nature communications 20160108
Sexual reproduction is crucially dependent on meiosis, a conserved, specialized cell division programme that is essential for the production of haploid gametes. Here we demonstrate that fertility and the implementation of the meiotic programme require a previously uncharacterized meiosis-specific protein, MEIOC. Meioc invalidation in mice induces early and pleiotropic meiotic defects in males and females. MEIOC prevents meiotic transcript degradation and interacts with an RNA helicase that binds ...[more]