Proteomics

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Proteomic analysis of sweat samples from tuberculosis patients

ABSTRACT: We performed a global proteomic profile of eccrine sweat sampled from patients with active pulmonary TB, other lung diseases (non-TB disease), and healthy controls. A comparison of proteomics results between Active-TB, Non-TB and Healthy Controls was done in search for proteins unique to the active TB-patient cohort as well as proteins unique to those without TB disease. We conclude tthat global proteomic profiling of eccrine sweat collected from TB and non-TB patients is a viable approach for the identification of unique proteins differentially present based on clinical cohort. These proteins may represent unique biomarker profiles that upon further verification and validation could be used to develop a non-sputum based test for diagnosis of active TB.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Skin, Sweat

DISEASE(S): Pulmonary Tuberculosis

SUBMITTER: Lisa Wolfe  

LAB HEAD: Jessica E. Prenni

PROVIDER: PXD003224 | Pride | 2016-03-14

REPOSITORIES: Pride

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Proteomic profiling of eccrine sweat reveals its potential as a diagnostic biofluid for active tuberculosis.

Adewole Olanisun Olufemi OO   Erhabor Greg Efosa GE   Adewole Temitayo Oluwatoyin TO   Ojo Abiodun Oluwasesan AO   Oshokoya Harriet H   Wolfe Lisa M LM   Prenni Jessica E JE  

Proteomics. Clinical applications 20160401 5

<h4>Purpose</h4>Excessive sweating is a common symptom of the disease and an unexplored biofluid for TB diagnosis; we conducted a proof-of-concept study to identify potential diagnostic biomarkers of active TB in eccrine sweat.<h4>Experimental design</h4>We performed a global proteomic profile of eccrine sweat sampled from patients with active pulmonary TB, other lung diseases (non-TB disease), and healthy controls. A comparison of proteomics between Active-TB, Non-TB, and Healthy Controls was d  ...[more]

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