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Human salivary extracellulae vesicles LC-MS/MS

ABSTRACT: using a facile method to prepare human salivary extracellular vesicles, and using LC-MS/MS to analysis the salivary extracellular vesicles proteomic. then we compared the healty donors with the lung cancer to discover potential biomarker.

INSTRUMENT(S): maXis

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Saliva

SUBMITTER: yan sun

LAB HEAD: hua xiao

PROVIDER: PXD003269 | Pride | 2018-10-25

REPOSITORIES: Pride

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Facile preparation of salivary extracellular vesicles for cancer proteomics.

Sun Yan Y Xia Zhijun Z Shang Zhi Z Sun Kaibo K Niu Xiaomin X Qian Liqiang L Fan Liu-Yin LY Cao Cheng-Xi CX Xiao Hua H

Scientific reports 20160419

Extracellular vesicles (EVs) are membrane surrounded structures released by cells, which have been increasingly recognized as mediators of intercellular communication. Recent reports indicate that EVs participate in important biological processes and could serve as potential source for cancer biomarkers. As an attractive EVs source with merit of non-invasiveness, human saliva is a unique medium for clinical diagnostics. Thus, we proposed a facile approach to prepare salivary extracellular vesicl ...[more]

PMID: 27091080

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