Xanthine Oxidoreductase mediates milk fat globule secretion.
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Mus Musculus (mouse)
SUBMITTER: 
Matthew Wither
LAB HEAD: Jenifer Monks
PROVIDER: PXD003336 | Pride | 2017-05-31
REPOSITORIES: Pride
Publications
Xanthine oxidoreductase mediates membrane docking of milk-fat droplets but is not essential for apocrine lipid secretion.
Monks Jenifer J Dzieciatkowska Monika M Bales Elise S ES Orlicky David J DJ Wright Richard M RM McManaman James L JL
The Journal of physiology 20160803 20
<h4>Key points</h4>Xanthine oxidoreductase (XOR) modulates milk lipid secretion and lactation initiation. XOR is required for butyrophilin1a1 clustering in the membrane during milk lipid secretion. XOR mediates apical membrane reorganization during milk lipid secretion. Loss of XOR delays milk fat globule secretion. XOR loss alters the proteome of milk fat globules.<h4>Abstract</h4>Apocrine secretion is utilized by epithelial cells of exocrine glands. These cells bud off membrane-bound particles ...[more]
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