Inner ear proteomics/transcriptomics

ABSTRACT: The correlation between expression levels of mRNA and protein in mammals is relatively low, with a Pearson correlation coefficient of ~0.40. Post transcriptional regulation contributes to this low correlation. Across taxa, it was demonstrated that translation efficiency, i.e. the protein-to-mRNA ratio in steady state, varies between species in a direction that buffers the protein levels from changes in the transcript abundance. Evidence for this behavior in tissues is sparse. We asked whether this phenomenon is evident in our auditory system data, and on previously obtained proteomic and transcriptomic data from different tissue datasets.

OTHER RELATED OMICS DATASETS IN: PRJNA306479

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Sensory Epithelial Cell, Inner Ear

SUBMITTER: Yair Pozniak  

LAB HEAD: Tamar Geiger

PROVIDER: PXD003379 | Pride | 2017-04-24

REPOSITORIES: Pride