Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Primary Neuron, Cell Culture
DISEASE(S): Alzheimer's Disease
SUBMITTER: Peer-Hendrik Kuhn
LAB HEAD: Prof. Dr. Stefan F. Lichtenthaler
PROVIDER: PXD003426 | Pride | 2018-10-18
REPOSITORIES: Pride
eLife 20160123
Metzincin metalloproteases have major roles in intercellular communication by modulating the function of membrane proteins. One of the proteases is the a-disintegrin-and-metalloprotease 10 (ADAM10) which acts as alpha-secretase of the Alzheimer's disease amyloid precursor protein. ADAM10 is also required for neuronal network functions in murine brain, but neuronal ADAM10 substrates are only partly known. With a proteomic analysis of Adam10-deficient neurons we identified 91, mostly novel ADAM10 ...[more]