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Multiparameter functional diversity of human C2H2 zinc finger proteins

ABSTRACT: We have identified protein protein interactions of 118 C2H2 zinc finger proteins by AP-MS using GFP-tagged constructs in order to understand their role in transcription regulation.

OTHER RELATED OMICS DATASETS IN: PRJNA307572PRJNA307565PRJNA307573

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell

SUBMITTER: Sadhna Phanse

LAB HEAD: Jack Greenblatt

PROVIDER: PXD003431 | Pride | 2016-12-09

REPOSITORIES: Pride

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Multiparameter functional diversity of human C2H2 zinc finger proteins.

Schmitges Frank W FW Radovani Ernest E Najafabadi Hamed S HS Barazandeh Marjan M Campitelli Laura F LF Yin Yimeng Y Jolma Arttu A Zhong Guoqing G Guo Hongbo H Kanagalingam Tharsan T Dai Wei F WF Taipale Jussi J Emili Andrew A Greenblatt Jack F JF Hughes Timothy R TR

Genome research 20161116 12

C2H2 zinc finger proteins represent the largest and most enigmatic class of human transcription factors. Their C2H2-ZF arrays are highly variable, indicating that most will have unique DNA binding motifs. However, most of the binding motifs have not been directly determined. In addition, little is known about whether or how these proteins regulate transcription. Most of the ∼700 human C2H2-ZF proteins also contain at least one KRAB, SCAN, BTB, or SET domain, suggesting that they may have common ...[more]

PMID: 27852650

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