Proteomics of Primary cells derived from Ovarian Cancer
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Primary Cell
DISEASE(S): Malignant Neoplasm Of Ovary
SUBMITTER: 
Chiara Francavilla
LAB HEAD: Jesper V. Olsen
PROVIDER: PXD003531 | Pride | 2017-04-03
REPOSITORIES: Pride
Publications
Phosphoproteomics of Primary Cells Reveals Druggable Kinase Signatures in Ovarian Cancer.
Francavilla Chiara C Lupia Michela M Tsafou Kalliopi K Villa Alessandra A Kowalczyk Katarzyna K Rakownikow Jersie-Christensen Rosa R Bertalot Giovanni G Confalonieri Stefano S Brunak Søren S Jensen Lars J LJ Cavallaro Ugo U Olsen Jesper V JV
Cell reports 20170301 13
Our understanding of the molecular determinants of cancer is still inadequate because of cancer heterogeneity. Here, using epithelial ovarian cancer (EOC) as a model system, we analyzed a minute amount of patient-derived epithelial cells from either healthy or cancerous tissues by single-shot mass-spectrometry-based phosphoproteomics. Using a multi-disciplinary approach, we demonstrated that primary cells recapitulate tissue complexity and represent a valuable source of differentially expressed ...[more]
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