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Pasteurella multocida Hfq mutant

ABSTRACT: Quantitative proteomics comparison wt and Hfq mutant Pasteurella multocida strains.

OTHER RELATED OMICS DATASETS IN: PRJNA311305

INSTRUMENT(S): Q Exactive

ORGANISM(S): Pasteurella Multocida Subsp. Multocida Str. Pm70

SUBMITTER: Oded Kleifeld

LAB HEAD: John Boyce

PROVIDER: PXD003586 | Pride | 2016-03-14

REPOSITORIES: Pride

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The RNA-Binding Chaperone Hfq Is an Important Global Regulator of Gene Expression in Pasteurella multocida and Plays a Crucial Role in Production of a Number of Virulence Factors, Including Hyaluronic Acid Capsule.

Mégroz Marianne M Kleifeld Oded O Wright Amy A Powell David D Harrison Paul P Adler Ben B Harper Marina M Boyce John D JD

Infection and immunity 20160422 5

The Gram-negative bacterium Pasteurella multocida is the causative agent of a number of economically important animal diseases, including avian fowl cholera. Numerous P. multocida virulence factors have been identified, including capsule, lipopolysaccharide (LPS), and filamentous hemagglutinin, but little is known about how the expression of these virulence factors is regulated. Hfq is an RNA-binding protein that facilitates riboregulation via interaction with small noncoding RNA (sRNA) molecule ...[more]

PMID: 26883595

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