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Mouse retinal tissue study in VEGF-induced hyperpermeability.

ABSTRACT: The goal of the project is to identify novel therapeutic targets for retinal vascular hyperpermeability. Three condition (Control, VEGF, and Anti-VEGF) sample of mouse retinal tissues were extensively characterized by global proteome profiling.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Retina

SUBMITTER: Dong-Gi Mun

LAB HEAD: Sang-Won Lee

PROVIDER: PXD003656 | Pride | 2016-03-22

REPOSITORIES: Pride

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Quantitative Proteomics Reveals β2 Integrin-mediated Cytoskeletal Rearrangement in Vascular Endothelial Growth Factor (VEGF)-induced Retinal Vascular Hyperpermeability.

Jo Dong Hyun DH Bae Jingi J Chae Sehyun S Kim Jin Hyoung JH Han Jong-Hee JH Hwang Daehee D Lee Sang-Won SW Kim Jeong Hun JH

Molecular & cellular proteomics : MCP 20160311 5

Retinal vascular hyperpermeability causes macular edema, leading to visual deterioration in retinal diseases such as diabetic retinopathy and retinal vascular occlusion. Dysregulation of junction integrity between endothelial cells by vascular endothelial growth factor (VEGF) was shown to cause retinal vascular hyperpermeability. Accordingly, anti-VEGF agents have been used to treat retinal vascular hyperpermeability. However, they can confer potential toxicity through their deleterious effects ...[more]

PMID: 26969716

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