Ontology highlight
ABSTRACT:
INSTRUMENT(S): 6520 Quadrupole Time-of-Flight LC/MS
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
DISEASE(S): Alzheimer's Disease
SUBMITTER: John Wishnok
LAB HEAD: Steven R. Tannenbaum
PROVIDER: PXD003802 | Pride | 2016-03-31
REPOSITORIES: Pride
Proceedings of the National Academy of Sciences of the United States of America 20160324 15
Protein S-nitrosation (SNO-protein), the nitric oxide-mediated posttranslational modification of cysteine thiols, is an important regulatory mechanism of protein function in both physiological and pathological pathways. A key first step toward elucidating the mechanism by which S-nitrosation modulates a protein's function is identification of the targeted cysteine residues. Here, we present a strategy for the simultaneous identification of SNO-cysteine sites and their cognate proteins to profile ...[more]