Dataset Information
CLK IP-MS - CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion ETD
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Christopher Hughes
LAB HEAD: Gregg Morin
PROVIDER: PXD003839 | Pride | 2017-03-14
REPOSITORIES: Pride
Publications
CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor.
Nature communications 20170223 1
CDC-like kinase phosphorylation of serine/arginine-rich proteins is central to RNA splicing reactions. Yet, the genomic network of CDC-like kinase-dependent RNA processing events remains poorly defined. Here, we explore the connectivity of genomic CDC-like kinase splicing functions by applying graduated, short-exposure, pharmacological CDC-like kinase inhibition using a novel small molecule (T3) with very high potency, selectivity, and cell-based stability. Using RNA-Seq, we define CDC-like kina ...[more]
