Proteomics

Dataset Information

50

Reticulocytes vs mature red blood cell


ABSTRACT: comparative study reticulocytes vs mature red blood cell

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo sapiens  

TISSUE(S): Blood

DISEASE(S): Plasmodium Falciparum Malaria

SUBMITTER: Siu Kwan Sze  

LAB HEAD: Newman Sze

PROVIDER: PXD003851 | Pride | 2017-11-09

REPOSITORIES: Pride

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Publications


Erythropoiesis is marked by progressive changes in morphological, biochemical and mechanical properties of erythroid precursors to generate red blood cells (RBC). The earliest enucleated forms derived in this process, known as reticulocytes, are multi-lobular and spherical. As reticulocytes mature, they undergo a series of dynamic cytoskeletal re-arrangements and the expulsion of residual organelles, resulting in highly deformable biconcave RBCs (normocytes). To understand the significant, yet n  ...[more]

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