Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Synovia
SUBMITTER: Pekka Rappu
LAB HEAD: Jyrki Heino
PROVIDER: PXD004017 | Pride | 2017-08-15
REPOSITORIES: Pride
Sipilä Kalle H KH Ranga Vipin V Rappu Pekka P Mali Markku M Pirilä Laura L Heino Ilona I Jokinen Johanna J Käpylä Jarmo J Johnson Mark S MS Heino Jyrki J
Scientific reports 20170815 1
We report the extent, specific sites and structural requirements of joint inflammation related citrullination in extracellular proteins. A total of 40 synovial fluid samples derived from chronically inflamed human joints were analysed by heparin-agarose fractionation and LC-MS/MS. Citrullination of 55 arginines in extracellular proteins was detected. Importantly, 20% of the sites have a characterized function related to the hallmarks of destructive joint inflammation. E.g. four arginine residues ...[more]