Proteomics

Dataset Information

0

Extracellular citrullination in synovial fluid


ABSTRACT: Citrullination of the proteins found in synovial fluid patient samples

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Synovia

SUBMITTER: Pekka Rappu  

LAB HEAD: Jyrki Heino

PROVIDER: PXD004017 | Pride | 2017-08-15

REPOSITORIES: Pride

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Publications

Joint inflammation related citrullination of functional arginines in extracellular proteins.

Sipilä Kalle H KH   Ranga Vipin V   Rappu Pekka P   Mali Markku M   Pirilä Laura L   Heino Ilona I   Jokinen Johanna J   Käpylä Jarmo J   Johnson Mark S MS   Heino Jyrki J  

Scientific reports 20170815 1


We report the extent, specific sites and structural requirements of joint inflammation related citrullination in extracellular proteins. A total of 40 synovial fluid samples derived from chronically inflamed human joints were analysed by heparin-agarose fractionation and LC-MS/MS. Citrullination of 55 arginines in extracellular proteins was detected. Importantly, 20% of the sites have a characterized function related to the hallmarks of destructive joint inflammation. E.g. four arginine residues  ...[more]

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