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Protein expression in the prefrontal cortex of aged mice with progranulin deficiency or neuronal progranulin overexpression

ABSTRACT: Description: Progranulin deficiency is associated with neurodegeneration in humans and in mice. We performed a deep proteomic screen of the pre-frontal cortex in aged (13-15 months) female progranulin-deficient mice (GRN-/-) and mice with a neuron-specific inducible overexpression of progranulin (SLICK-GRN-OE with tamoxifen) versus the respective control mice (Grn+/+ and SLICK-Grn without Tamoxifen). The data set shows progranulin-dependent alterations of protein expression in the cortex of mice.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Ilka Wittig

LAB HEAD: Irmgard Tegeder

PROVIDER: PXD004087 | Pride | 2016-10-13

REPOSITORIES: Pride

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Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy.

Altmann Christine C Hardt Stefanie S Fischer Caroline C Heidler Juliana J Lim Hee-Young HY Häussler Annett A Albuquerque Boris B Zimmer Béla B Möser Christine C Behrends Christian C Koentgen Frank F Wittig Ilka I Schmidt Mirko H H MHH Clement Albrecht M AM Deller Thomas T Tegeder Irmgard I

Neurobiology of disease 20160911

Peripheral or central nerve injury is a frequent cause of chronic pain and the mechanisms are not fully understood. Using newly generated transgenic mice we show that progranulin overexpression in sensory neurons attenuates neuropathic pain after sciatic nerve injury and accelerates nerve healing. A yeast-2-hybrid screen revealed putative interactions of progranulin with autophagy-related proteins, ATG12 and ATG4b. This was supported by colocalization and proteomic studies showing regulations of ...[more]

PMID: 27629805

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