Proteomic profile of two different cerebral hypoxic models treated with antioxidant melatonin and nitric oxide donors
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Brain
DISEASE(S): Brain Hypoxia-ischemia
SUBMITTER: 
Santos Blanco
LAB HEAD: Maria Angeles Peinado
PROVIDER: PXD004091 | Pride | 2017-07-17
REPOSITORIES: Pride
Publications
Comparative proteomic study of early hypoxic response in the cerebral cortex of rats submitted to two different hypoxic models.
Ovelleiro David D Blanco Santos S Hernández Raquel R Peinado María Ángeles MÁ
Proteomics. Clinical applications 20170822 11-12
<h4>Purpose</h4>The present study analyses and compares the cortical brain proteomic profiles of two different models of cerebral hypoxic insult in rats (HH: hypobaric hypoxia and HHI: ischemia followed by hypobaric hypoxia) in an attempt to describe the alterations of the early molecular hypoxic adaptive response underlying each one.<h4>Experimental design</h4>A quantitative proteomic profile of left-brain cortices of rats under HH, HHI, and control conditions was determined using isobaric labe ...[more]
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