Canine Flexor Tendon Healing - Effect of adipose-derived stromal cells and BMP12 on intrasynovial tendon repair: A biomechanical, biochemical, and proteomics study

ABSTRACT: The project investigated the changes in proteomics profile of canine flexor digitorum profundus tendons 28 days after tendon transection and surgical repair with (ASCs+BMP12) or without a stem cell and growth factor based treatment (repair only). Specifically, adipose-derived mesenchymal stromal cells together with BMP12 were delivered with a polymer scaffold consisting of multiple alternating layers of a heparin/fibrin-based delivery system and a polylactic co-glycolic acid (PLGA) scaffold. Non-operated tendons from contralateral digits were used as normal control (Normal).

INSTRUMENT(S):

ORGANISM(S): Canis Familiaris (dog) (canis Lupus Familiaris)

TISSUE(S): Stem Cell, Tendon

DISEASE(S): Wounds And Injuries

SUBMITTER: Hua Shen  

LAB HEAD: Richard H Gelberman

PROVIDER: PXD004097 | Pride | 2017-06-12

REPOSITORIES: Pride