Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos, Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Liver
SUBMITTER: Ulrich auf dem Keller
LAB HEAD: Sabine Werner
PROVIDER: PXD004108 | Pride | 2017-09-13
REPOSITORIES: Pride
Developmental cell 20170907 6
The liver is the only organ in mammals that fully regenerates even after major injury. To identify orchestrators of this regenerative response, we performed quantitative large-scale proteomics analysis of cytoplasmic and nuclear fractions from normal versus regenerating mouse liver. Proteins of the ubiquitin-proteasome pathway were rapidly upregulated after two-third hepatectomy, with the ubiquitin ligase Nedd4-1 being a top hit. In vivo knockdown of Nedd4-1 in hepatocytes through nanoparticle-m ...[more]