Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA338478
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Macrophage
SUBMITTER: Aleksandra Nita-Lazar
LAB HEAD: Aleksandra Nita-Lazar
PROVIDER: PXD004113 | Pride | 2017-03-06
REPOSITORIES: Pride
Molecular & cellular proteomics : MCP 20170224 4 suppl 1
The innate immune system is the organism's first line of defense against pathogens. Pattern recognition receptors (PRRs) are responsible for sensing the presence of pathogen-associated molecules. The prototypic PRRs, the membrane-bound receptors of the Toll-like receptor (TLR) family, recognize pathogen-associated molecular patterns (PAMPs) and initiate an innate immune response through signaling pathways that depend on the adaptor molecules MyD88 and TRIF. Deciphering the differences in the com ...[more]