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N2 versus octr-1 shotgun proteomics nano MS/MS

ABSTRACT: by using a mass spectrometry-based quantitative proteomics approach, we discovered that OCTR-1 regulates innate immunity by suppressing translation and the unfolded protein response (UPR) pathways at the protein level.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Caenorhabditis Elegans

TISSUE(S): Whole Body

SUBMITTER: DURAI SELLEGOUNDER

LAB HEAD: Jingru Sun

PROVIDER: PXD004173 | Pride | 2016-12-22

REPOSITORIES: Pride

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Neuronal GPCR OCTR-1 regulates innate immunity by controlling protein synthesis in Caenorhabditis elegans.

Liu Yiyong Y Sellegounder Durai D Sun Jingru J

Scientific reports 20161111

Upon pathogen infection, microbial killing pathways and cellular stress pathways are rapidly activated by the host innate immune system. These pathways must be tightly regulated because insufficient or excessive immune responses have deleterious consequences. Increasing evidence indicates that the nervous system regulates the immune system to confer coordinated protection to the host. However, the precise mechanisms of neural-immune communication remain unclear. Previously we have demonstrated t ...[more]

PMID: 27833098

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