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TFG Cell-derived matrix proteome

ABSTRACT: Examining the effect of RNAi-mediated depletion of TFG on extracellular matrix secretion

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

SUBMITTER: David Stephens

LAB HEAD: David Stephens

PROVIDER: PXD004175 | Pride | 2016-05-20

REPOSITORIES: Pride

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TFG Promotes Organization of Transitional ER and Efficient Collagen Secretion.

McCaughey Janine J Miller Victoria J VJ Stevenson Nicola L NL Brown Anna K AK Budnik Annika A Heesom Kate J KJ Alibhai Dominic D Stephens David J DJ

Cell reports 20160512 8

Collagen is the most abundant protein in the animal kingdom. It is of fundamental importance during development for cell differentiation and tissue morphogenesis as well as in pathological processes such as fibrosis and cancer cell migration. However, our understanding of the mechanisms of procollagen secretion remains limited. Here, we show that TFG organizes transitional ER (tER) and ER exit sites (ERESs) into larger structures. Depletion of TFG results in dispersion of tER elements that remai ...[more]

PMID: 27184855

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