Dataset Information

Plasma Biomarker Profile Altered Through Variable Blood Storage

ABSTRACT: A major confounding factor for defining disease-specific molecular signatures is the variation in handling and processing of clinical samples. To address this, we assessed how the plasma proteome and degradome changes when whole blood remains at ambient temperature (AT) following collection and prior to processing.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Philip Charles

LAB HEAD: Benedikt Kessler

PROVIDER: PXD004205 | Pride | 2018-10-26

REPOSITORIES: Pride

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Plasma degradome affected by variable storage of human blood.

Kaisar Maria M van Dullemen Leon F A LFA Thézénas Marie-Laëtitia ML Zeeshan Akhtar M M Huang Honglei H Rendel Sandrine S Charles Philip D PD Fischer Roman R Ploeg Rutger J RJ Kessler Benedikt M BM

Clinical proteomics 20160926

<h4>Background</h4>The successful application of-omics technologies in the discovery of novel biomarkers and targets of therapeutic interventions is facilitated by large collections of well curated clinical samples stored in bio banks. Mining the plasma proteome holds promise to improve our understanding of disease mechanisms and may represent a source of biomarkers. However, a major confounding factor for defining disease-specific proteomic signatures in plasma is the variation in handling and ...[more]

PMID: 27708557

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