Nano-liquid chromatography-orbitrap MS/MS-based quantitative proteomics reveals differences between the mechanisms of action of carnosic acid and carnosol in colon cancer cells

ABSTRACT: A shotgun proteomics study based on stable isotope dimethyl labeling (DML) and nano liquid chromatography-tandem mass spectrometry (nano-LC-MS/MS) has been performed to identify the relative changes in proteins and to gain some light on the specific molecular targets and mechanisms of action of CA and CS in HT-29 colon cancer cells.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Colonic Cancer Cell Line, Epithelial Cell

DISEASE(S): Colon Adenocarcinoma

SUBMITTER: Alberto Valdés  

LAB HEAD: Alejandro Cifuentes

PROVIDER: PXD004253 | Pride | 2016-12-23

REPOSITORIES: Pride