Proteomics

Dataset Information

0

Comprehensive proteomic analysis of human erythropoiesis - experiment 4 over 4


ABSTRACT: We performed a proteomic analysis of human erythropoiesis using 4 umbilical cord's blood samples. This study revealed the absolute and quantitative expression of more than 6000 proteins throughout 7 stages of erythroid differentiation using a label-free technique. We found new informations on erythropoiesis such as unexpected protein expression depicted the article.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Umbilical Cord Blood Cell, Erythroblast

SUBMITTER: François GUILLONNEAU  

LAB HEAD: Patrick Mayeux

PROVIDER: PXD004316 | Pride | 2016-08-08

REPOSITORIES: Pride

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Publications


Mass spectrometry-based proteomics now enables the absolute quantification of thousands of proteins in individual cell types. We used this technology to analyze the dynamic proteome changes occurring during human erythropoiesis. We quantified the absolute expression of 6,130 proteins during erythroid differentiation from late burst-forming units-erythroid (BFU-Es) to orthochromatic erythroblasts. A modest correlation between mRNA and protein expression was observed. We identified several protein  ...[more]

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