Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos, Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Spleen, T Cell, Regulatory T Cell, Lymph Node
SUBMITTER: Anne Gonzalez de Peredo
LAB HEAD: Anne Gonzale de Peredo
PROVIDER: PXD004436 | Pride | 2017-04-10
REPOSITORIES: Pride
Duguet Fanny F Locard-Paulet Marie M Marcellin Marlène M Chaoui Karima K Bernard Isabelle I Andreoletti Olivier O Lesourne Renaud R Burlet-Schiltz Odile O Gonzalez de Peredo Anne A Saoudi Abdelhadi A
Molecular & cellular proteomics : MCP 20170403 8
Regulatory T cells (Treg) represent a minor subpopulation of T lymphocytes that is crucial for the maintenance of immune homeostasis. Here, we present a large-scale quantitative mass spectrometry study that defines a specific proteomic "signature" of Treg. Treg and conventional T lymphocyte (Tconv) subpopulations were sorted by flow cytometry and subjected to global proteomic analysis by single-run nanoLC-MS/MS on a fast-sequencing Q-Exactive mass spectrometer. Besides "historical" proteins that ...[more]