Time-course global proteome analyses in the APPNL-F mouse model of Alzheimer disease

ABSTRACT: A hallmark of Alzheimer Disease is the accumulation of aggregation-prone amyloid beta peptides, which can assemble into smaller aggregates and deposit in the form of amyloid plaques. Here we used the recently introduced APPNL-F mouse model of Alzheimer Disease, which faithfully recapitulates the amyloid beta pathology of the disease, to identify early changes to the global proteome. Using a workflow that interrogated the brain proteome of these mice by quantitative mass spectrometry at five, ten and fifteen months of age.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: Declan Williams  

LAB HEAD: Gerold Schmitt-Ulms

PROVIDER: PXD004439 | Pride | 2017-08-02

REPOSITORIES: Pride