Proteomics

Dataset Information

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Blood coagulation and complement activation interact to increase disease activity in systemic lupus erythematosus and coagulation D-Dimer combined with complement C4 is a biomarker of lupus activity


ABSTRACT: This study was conducted to (1) find deregulation of certain pathways in SLE at multi-omics levels; (2) evaluate the associations among blood coagulation, complement activation, inflammatory responses and SLE disease severity; (3) develop biomarkers to facilitate better the assessment of the likelihood of lupus activity.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood

SUBMITTER: shangbo xie  

LAB HEAD: Dong-Qing Ye

PROVIDER: PXD004443 | Pride | 2018-10-27

REPOSITORIES: Pride

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Publications

Coagulation cascade and complement system in systemic lupus erythematosus.

Liang Yan Y   Xie Shang-Bo SB   Wu Chang-Hao CH   Hu Yuan Y   Zhang Qin Q   Li Si S   Fan Yin-Guang YG   Leng Rui-Xue RX   Pan Hai-Feng HF   Xiong Hua-Bao HB   Ye Dong-Qing DQ  

Oncotarget 20171211 19


This study was conducted to (1) characterize coagulation cascade and complement system in systemic lupus erythematosus (SLE); (2) evaluate the associations between coagulation cascade, complement system, inflammatory response and SLE disease severity; (3) test the diagnostic value of a combination of D-dimer and C4 for lupus activity. Transcriptomics, proteomics and metabolomics were performed in 24 SLE patients and 24 healthy controls. The levels of ten coagulations, seven complements and three  ...[more]

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