Proteomics

Dataset Information

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Glycoproteomics reveals the presence of decorin peptides with anti-myostatin activity in human atrial fibrillation

ABSTRACT: We analysed by proteomics the cardiac extraceelular matrix in human atrial fibrillation and disvovered the presence of extracellular matrix protein fragments that can regulate cardiac cell physiology

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Heart

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Javier Barallobre-Barreiro  

LAB HEAD: Manuel Mayr

PROVIDER: PXD004465 | Pride | 2016-09-29

REPOSITORIES: Pride

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Dataset's files

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Action DRS
F013939.dat-pride.pride.mgf.gz Mgf
F013939.dat-pride.pride.mztab.gz Mztab
F013939.dat-pride.xml.gz Xml
F013940.dat-pride.pride.mgf.gz Mgf
F013940.dat-pride.pride.mztab.gz Mztab
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Publications

<h4>Background</h4>Myocardial fibrosis is a feature of many cardiac diseases. We used proteomics to profile glycoproteins in the human cardiac extracellular matrix (ECM).<h4>Methods</h4>Atrial specimens were analyzed by mass spectrometry after extraction of ECM proteins and enrichment for glycoproteins or glycopeptides.<h4>Results</h4>ECM-related glycoproteins were identified in left and right atrial appendages from the same patients. Several known glycosylation sites were confirmed. In addition  ...[more]