Proteomics

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Quantitative proteomic analysis of human malignant ascites


ABSTRACT: Ascites is a valuable source of cancer biomarkers, because it contains a variety of secreted and shed proteins from cancerous cells. Conversely, most proteomic studies on ascites have focused on ovarian cancer and provided insufficient depth for biomarker discovery. Further, no proteomic analysis of ascites from gastric cancer has been reported. To this end, we profiled the human ascites proteome to obtain a pool of biomarker candidates using comprehensive proteomic strategies. Subsequently, label-free quantitation was performed to compare the abundance of proteins between benign disease and gastric cancer patients.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

DISEASE(S): Stomach Cancer

SUBMITTER: Dohyun Han  

LAB HEAD: Dohyun Han

PROVIDER: PXD004501 | Pride | 2018-04-16

REPOSITORIES: Pride

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Publications

Comparative proteomic analysis of human malignant ascitic fluids for the development of gastric cancer biomarkers.

Jin Jonghwa J   Son Minsoo M   Kim Hyeyoon H   Kim Hyeyeon H   Kong Seong-Ho SH   Kim Hark Kyun HK   Kim Youngsoo Y   Han Dohyun D  

Clinical biochemistry 20180411


<h4>Objectives</h4>Malignant ascites is a sign of peritoneal seeding, which is one of the most frequent forms of incurable distant metastasis. Because the development of malignant ascites is associated with an extremely poor prognosis, determining whether it resulted from peritoneal seeding has critical clinical implications in diagnosis, choice of treatment, and active surveillance. At present, the molecular characterizations of malignant ascites are especially limited in case of gastric cancer  ...[more]

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