Dataset Information
Mapping and Quantification of Brain Protein O-GlcNAcylation in Alzheimer’s Disease
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cerebral Gray Matter
DISEASE(S): Alzheimer's Disease
SUBMITTER: 
Matthew Monroe
LAB HEAD: Tao Liu
PROVIDER: PXD004510 | Pride | 2017-09-04
REPOSITORIES: Pride
Publications
Quantitative proteomics identifies altered O-GlcNAcylation of structural, synaptic and memory-associated proteins in Alzheimer's disease.
The Journal of pathology 20170728 1
Protein modification by O-linked β-N-acetylglucosamine (O-GlcNAc) is emerging as an important factor in the pathogenesis of sporadic Alzheimer's disease (AD); however, detailed molecular characterization of this important protein post-translational modification at the proteome level has been highly challenging, owing to its low stoichiometry and labile nature. Herein, we report the most comprehensive, quantitative proteomics analysis for protein O-GlcNAcylation in postmortem human brain tissues ...[more]
