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Pseudomonas aeroginosa resistant against Ciprofloxacin

ABSTRACT: To indentify protein networks and proteins involved in Ciprofloxacin resistance developed by Pseudomonas aeruginosa

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Pseudomonas Aeruginosa Pao1

SUBMITTER: Jianhe Peng

LAB HEAD: Jianhe Peng

PROVIDER: PXD004560 | Pride | 2016-12-12

REPOSITORIES: Pride

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Pseudomonas aeruginosa develops Ciprofloxacin resistance from low to high level with distinctive proteome changes.

Peng Jianhe J Cao Jing J Ng Fui Mee FM Hill Jeffrey J

Journal of proteomics 20161019

Pseudomonas aeruginosa infection is difficult to treat because of its drug resistance, but how it develops drug resistance remains largely unknown. In this study we investigated Ciprofloxacin resistance development in P. aeruginosa. Different Ciprofloxacin concentrations selected different low level resistant mutants, and high level resistant mutants emerged from low level resistant mutants if stressed further by Ciprofloxacin. A deep quantitative proteomic study of the Ciprofloxacin resistant m ...[more]

PMID: 27771372

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