Proteomics

Dataset Information

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Liquid Chromatography Ion Mobility Mass Spectrometry analysis of CPTAC Comparator Reference sample CompRef P6

ABSTRACT: Proteomic discovery and targeted monitoring of proteins in a breast cancer xenograft tissue sample using LC Ion Mobility Mass Spectrometry.

INSTRUMENT(S): LTQ Orbitrap Velos, Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Breast Cancer Cell

DISEASE(S): Breast Cancer

SUBMITTER: Matthew Monroe  

LAB HEAD: Richard D. Smith

PROVIDER: PXD004569 | Pride | 2016-08-10

REPOSITORIES: Pride

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Publications

Simultaneous Proteomic Discovery and Targeted Monitoring using Liquid Chromatography, Ion Mobility Spectrometry, and Mass Spectrometry.

Burnum-Johnson Kristin E KE   Nie Song S   Casey Cameron P CP   Monroe Matthew E ME   Orton Daniel J DJ   Ibrahim Yehia M YM   Gritsenko Marina A MA   Clauss Therese R W TR   Shukla Anil K AK   Moore Ronald J RJ   Purvine Samuel O SO   Shi Tujin T   Qian Weijun W   Liu Tao T   Baker Erin S ES   Smith Richard D RD  

Molecular & cellular proteomics : MCP 20160925 12

Current proteomic approaches include both broad discovery measurements and quantitative targeted analyses. In many cases, discovery measurements are initially used to identify potentially important proteins (e.g. candidate biomarkers) and then targeted studies are employed to quantify a limited number of selected proteins. Both approaches, however, suffer from limitations. Discovery measurements aim to sample the whole proteome but have lower sensitivity, accuracy, and quantitation precision tha  ...[more]

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