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Inference and quantification of peptidoforms in large sample cohorts by SWATH-MS: Twin blood plasma quantitative variance components

ABSTRACT: This data set represents a reanalysis of human blood plasma samples measured by SWATH-MS of 36 pairs of monozygotic and 22 pairs of dizygotic twins that were sampled at two longitudinal time points (Liu et al., 2015, PMID:25652787). The data were used to determine the overall quantitative variability of 4322 peptidoforms in the sample cohort and to assign the measured variability to heritability, environmental or longitudinal effects.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: George Rosenberger

LAB HEAD: Ruedi Aebersold

PROVIDER: PXD004574 | Pride | 2017-06-06

REPOSITORIES: Pride

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Quantitative variability of 342 plasma proteins in a human twin population.

Liu Yansheng Y Buil Alfonso A Collins Ben C BC Gillet Ludovic C J LC Blum Lorenz C LC Cheng Lin-Yang LY Vitek Olga O Mouritsen Jeppe J Lachance Genevieve G Spector Tim D TD Dermitzakis Emmanouil T ET Aebersold Ruedi R

Molecular systems biology 20150204 1

The degree and the origins of quantitative variability of most human plasma proteins are largely unknown. Because the twin study design provides a natural opportunity to estimate the relative contribution of heritability and environment to different traits in human population, we applied here the highly accurate and reproducible SWATH mass spectrometry technique to quantify 1,904 peptides defining 342 unique plasma proteins in 232 plasma samples collected longitudinally from pairs of monozygotic ...[more]

PMID: 25652787

Publication: 1/2

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