Dataset Information
Serial co-immunoprecipitation to expand the protein interactome of the outer mitosomal membrane in Giardia lamblia
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Giardia Lamblia Atcc 50803
TISSUE(S): Eukaryotic Cell, Cell Culture
DISEASE(S): Giardiasis
SUBMITTER: 
Carmen Faso
LAB HEAD: Adrian B. Hehl
PROVIDER: PXD004583 | Pride | 2016-11-15
REPOSITORIES: Pride
Publications
An Interactome-Centered Protein Discovery Approach Reveals Novel Components Involved in Mitosome Function and Homeostasis in Giardia lamblia.
PLoS pathogens 20161207 12
Protozoan parasites of the genus Giardia are highly prevalent globally, and infect a wide range of vertebrate hosts including humans, with proliferation and pathology restricted to the small intestine. This narrow ecological specialization entailed extensive structural and functional adaptations during host-parasite co-evolution. An example is the streamlined mitosomal proteome with iron-sulphur protein maturation as the only biochemical pathway clearly associated with this organelle. Here, we a ...[more]
