Dataset Information
BRAF complexes - Discrete cytosolic macromolecular BRAF complexes exhibit distinct activities and composition
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
DISEASE(S): Colon Cancer
SUBMITTER: 
Joern Dengjel
LAB HEAD: Joern Dengjel
PROVIDER: PXD004585 | Pride | 2017-01-03
REPOSITORIES: Pride
Publications
Discrete cytosolic macromolecular BRAF complexes exhibit distinct activities and composition.
The EMBO journal 20170116 5
As a central element within the RAS/ERK pathway, the serine/threonine kinase BRAF plays a key role in development and homeostasis and represents the most frequently mutated kinase in tumors. Consequently, it has emerged as an important therapeutic target in various malignancies. Nevertheless, the BRAF activation cycle still raises many mechanistic questions as illustrated by the paradoxical action and side effects of RAF inhibitors. By applying SEC-PCP-SILAC, we analyzed protein-protein interact ...[more]
