Proteomics

Dataset Information

0

PCP39: prostate cancer proteome for 39 patients by PCT-SWATH


ABSTRACT: here we processed 105 biopsy-level tissues from 39 prostate cancer patients using pressure cycling technology (PCT) and SWATH-MS

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Prostate Adenocarcinoma Cell, Epithelial Cell

DISEASE(S): Prostate Adenocarcinoma

SUBMITTER: Tiannan Guo  

LAB HEAD: Ruedi Aebersold

PROVIDER: PXD004589 | Pride | 2018-10-17

REPOSITORIES: Pride

altmetric image

Publications


It remains unclear to what extent tumor heterogeneity impacts on protein biomarker discovery. Here, we quantified proteome intra-tissue heterogeneity (ITH) based on a multi-region analysis of prostate tissues using pressure cycling technology and SWATH mass spectrometry. We quantified 6,873 proteins and analyzed the ITH of 3,700 proteins. The level of ITH varied depending on proteins and tissue types. Benign tissues exhibited more complex ITH patterns than malignant tissues. Spatial variability  ...[more]

Similar Datasets

| E-PROT-2 | biostudies-arrayexpress
2018-08-13 | PXD003497 | Pride
2019-10-07 | PXD004691 | Pride
2015-02-04 | PXD000672 | Pride
2021-01-13 | PXD004701 | Pride
2020-06-01 | PXD003539 | Pride
2022-08-25 | PXD034891 | Pride
2019-10-21 | PXD009597 | Pride
2018-12-18 | PXD010869 | Pride
2021-09-15 | PXD027874 | Pride