Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Prostate Adenocarcinoma Cell, Epithelial Cell
DISEASE(S): Prostate Adenocarcinoma
SUBMITTER: Tiannan Guo
LAB HEAD: Ruedi Aebersold
PROVIDER: PXD004589 | Pride | 2018-10-17
REPOSITORIES: Pride
Guo Tiannan T Li Li L Zhong Qing Q Rupp Niels J NJ Charmpi Konstantina K Wong Christine E CE Wagner Ulrich U Rueschoff Jan H JH Jochum Wolfram W Fankhauser Christian Daniel CD Saba Karim K Poyet Cedric C Wild Peter J PJ Aebersold Ruedi R Beyer Andreas A
Life science alliance 20180501 2
It remains unclear to what extent tumor heterogeneity impacts on protein biomarker discovery. Here, we quantified proteome intra-tissue heterogeneity (ITH) based on a multi-region analysis of prostate tissues using pressure cycling technology and SWATH mass spectrometry. We quantified 6,873 proteins and analyzed the ITH of 3,700 proteins. The level of ITH varied depending on proteins and tissue types. Benign tissues exhibited more complex ITH patterns than malignant tissues. Spatial variability ...[more]