Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
DISEASE(S): Acute Leukemia
SUBMITTER: Daniel Perez Hernandez
LAB HEAD: Daniel Perez Hernandez
PROVIDER: PXD004606 | Pride | 2017-01-31
REPOSITORIES: Pride
Riesner Katarina K Shi Yu Y Jacobi Angela A Kräter Martin M Kalupa Martina M McGearey Aleixandria A Mertlitz Sarah S Cordes Steffen S Schrezenmeier Jens-Florian JF Mengwasser Jörg J Westphal Sabine S Perez-Hernandez Daniel D Perez-Hernandez Daniel D Schmitt Clemens C Dittmar Gunnar G Guck Jochen J Penack Olaf O
Blood 20170117 14
The inhibition of inflammation-associated angiogenesis ameliorates inflammatory diseases by reducing the recruitment of tissue-infiltrating leukocytes. However, it is not known if angiogenesis has an active role during the initiation of inflammation or if it is merely a secondary effect occurring in response to stimuli by tissue-infiltrating leukocytes. Here, we show that angiogenesis precedes leukocyte infiltration in experimental models of inflammatory bowel disease and acute graft-versus-host ...[more]