Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA327850
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Paola Vagnarelli
LAB HEAD: Paola Vagnarelli
PROVIDER: PXD004613 | Pride | 2016-12-07
REPOSITORIES: Pride
de Castro Inês J IJ Budzak James J Di Giacinto Maria L ML Ligammari Lorena L Gokhan Ezgi E Spanos Christos C Moralli Daniela D Richardson Christine C de Las Heras Jose I JI Salatino Silvia S Schirmer Eric C EC Ullman Katharine S KS Bickmore Wendy A WA Green Catherine C Rappsilber Juri J Lamble Sarah S Goldberg Martin W MW Vinciotti Veronica V Vagnarelli Paola P
Nature communications 20170116
Repo-Man is a protein phosphatase 1 (PP1) targeting subunit that regulates mitotic progression and chromatin remodelling. After mitosis, Repo-Man/PP1 remains associated with chromatin but its function in interphase is not known. Here we show that Repo-Man, via Nup153, is enriched on condensed chromatin at the nuclear periphery and at the edge of the nucleopore basket. Repo-Man/PP1 regulates the formation of heterochromatin, dephosphorylates H3S28 and it is necessary and sufficient for heterochro ...[more]