PP1 interactome during heart failure development

ABSTRACT: The PP1 interactome plays a central role in HF pathogenesis and is dysregulated at the level of the R-subunits in the failing heart, resulting in differential phosphorylation status of proteins across different subcellular compartments.With the combination if immunoaffinity purification and mass spectrometry we were able to map the PP1 interactome in a mouse model with dilated cardiomyopaty, which is the most common form of primary cardiomyopaty leading to HF.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)

TISSUE(S): Heart, Hela Cell

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Eleonora Corradini  

LAB HEAD: Albert J.R. Heck

PROVIDER: PXD004643 | Pride | 2018-04-11

REPOSITORIES: Pride