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Lipidomics reveals dramatic lipid compositional changes in the maturing postnatal lung

ABSTRACT: Lipidomics, proteomics and metabolomics characterization of the ontogeny of lipid, protein and metabolite changes during normal postnatal lung development

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Lung

SUBMITTER: Matthew Monroe

LAB HEAD: Charles Ansong

PROVIDER: PXD004651 | Pride | 2018-10-22

REPOSITORIES: Pride

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Lipidomics reveals dramatic lipid compositional changes in the maturing postnatal lung.

Dautel Sydney E SE Kyle Jennifer E JE Clair Geremy G Sontag Ryan L RL Weitz Karl K KK Shukla Anil K AK Nguyen Son N SN Kim Young-Mo YM Zink Erika M EM Luders Teresa T Frevert Charles W CW Gharib Sina A SA Laskin Julia J Carson James P JP Metz Thomas O TO Corley Richard A RA Ansong Charles C

Scientific reports 20170201

Lung immaturity is a major cause of morbidity and mortality in premature infants. Understanding the molecular mechanisms driving normal lung development could provide insights on how to ameliorate disrupted development. While transcriptomic and proteomic analyses of normal lung development have been previously reported, characterization of changes in the lipidome is lacking. Lipids play significant roles in the lung, such as dipalmitoylphosphatidylcholine in pulmonary surfactant; however, many o ...[more]

PMID: 28145528

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