Proteomics

Dataset Information

0

Protein profiling of 6-OHDA induced PD Model treated by TBN


ABSTRACT: Parkinson's disease (PD) listed as the second most common neurodegenerative disease. 2-[[(1,1-Dimethylethyl)oxidoimino]-methyl]-3,5,6-trimethylpyrazine (TBN), a novel nitrone derivative of tetramethylpyrazine, has shown benefits for the treatment both in vitro and in vivo, TBN protects and rescues dopaminergic neurons from MPP(+) and MPTP/6-OHDA-induced damage by reducing ROS and increasing cellular antioxidative defense capability. Here, we investigate the proteome changes in the 6-OHDA induced PD rat model and the rescue effects after treated by TBN.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain

DISEASE(S): Parkinson's Disease

SUBMITTER: Wei Ge  

LAB HEAD: Wei Ge

PROVIDER: PXD004812 | Pride | 2022-03-02

REPOSITORIES: Pride

Similar Datasets

2022-02-28 | PXD005089 | Pride
2019-02-28 | PXD009540 | Pride
2015-08-06 | E-GEOD-71681 | biostudies-arrayexpress
2020-07-17 | PXD010544 | Pride
2020-07-17 | PXD010543 | Pride
2017-03-29 | PXD004152 | Pride
2021-09-09 | PXD022840 | Pride
2021-09-09 | PXD022862 | Pride
2010-04-08 | E-GEOD-13442 | biostudies-arrayexpress
2023-01-01 | GSE198009 | GEO