Proteomics,Multiomics

Dataset Information

0

Spermidine treated mouse Heart LC-MS/MS

ABSTRACT: Label free quantification approach comparing hearts isolated from young, old, old + spermidine treated mice

OTHER RELATED OMICS DATASETS IN: PRJNA342821

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart

SUBMITTER: Joern Dengjel  

LAB HEAD: Joern Dengjel

PROVIDER: PXD004916 | Pride | 2016-12-23

REPOSITORIES: Pride

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Publications

Cardioprotection and lifespan extension by the natural polyamine spermidine.

Eisenberg Tobias T   Abdellatif Mahmoud M   Schroeder Sabrina S   Primessnig Uwe U   Stekovic Slaven S   Pendl Tobias T   Harger Alexandra A   Schipke Julia J   Zimmermann Andreas A   Schmidt Albrecht A   Tong Mingming M   Ruckenstuhl Christoph C   Dammbrueck Christopher C   Gross Angelina S AS   Herbst Viktoria V   Magnes Christoph C   Trausinger Gert G   Narath Sophie S   Meinitzer Andreas A   Hu Zehan Z   Kirsch Alexander A   Eller Kathrin K   Carmona-Gutierrez Didac D   Büttner Sabrina S   Pietrocola Federico F   Knittelfelder Oskar O   Schrepfer Emilie E   Rockenfeller Patrick P   Simonini Corinna C   Rahn Alexandros A   Horsch Marion M   Moreth Kristin K   Beckers Johannes J   Fuchs Helmut H   Gailus-Durner Valerie V   Neff Frauke F   Janik Dirk D   Rathkolb Birgit B   Rozman Jan J   de Angelis Martin Hrabe MH   Moustafa Tarek T   Haemmerle Guenter G   Mayr Manuel M   Willeit Peter P   von Frieling-Salewsky Marion M   Pieske Burkert B   Scorrano Luca L   Pieber Thomas T   Pechlaner Raimund R   Willeit Johann J   Sigrist Stephan J SJ   Linke Wolfgang A WA   Mühlfeld Christian C   Sadoshima Junichi J   Dengjel Joern J   Kiechl Stefan S   Kroemer Guido G   Sedej Simon S   Madeo Frank F  

Nature medicine 20161114 12

Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Spermidine feeding enhanced cardiac autophagy, mitophagy and mitochondrial respiration, and it also improved the mechano-elastical properties of cardiomyocytes in vivo, coinciding with increased titin ph  ...[more]

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