Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos, Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Sophia Doll
LAB HEAD: Sophia Doll
PROVIDER: PXD004945 | Pride | 2016-12-23
REPOSITORIES: Pride
Doll Sophia S Urisman Anatoly A Oses-Prieto Juan A JA Arnott David D Burlingame Alma L AL
Molecular & cellular proteomics : MCP 20161110 1
Glioblastoma multiformes (GBMs) are high-grade astrocytomas and the most common brain malignancies. Primary GBMs are often associated with disturbed RAS signaling, and expression of oncogenic HRAS results in a malignant phenotype in glioma cell lines. Secondary GBMs arise from lower-grade astrocytomas, have slower progression than primary tumors, and contain IDH1 mutations in over 70% of cases. Despite significant amount of accumulating genomic and transcriptomic data, the fundamental mechanisti ...[more]