Ska3-microtubule interactions - Ska3 Ensures Timely Mitotic Progression by Interacting Directly With Microtubules and Ska1 Microtubule Binding Domain

ABSTRACT: The Ndc 80 and Ska complex are the major microtubule-binding factors of the kinetochore responsible for maintaining chromosome-microtubule coupling during chromosome segregation. We previously showed that the Ska1 subunit of the Skacomlex binds dynamic microtubules. This project demonstrated that Ska3 subunit is required to modulate the microtubule binding capability of the Ska complex by directly interacting with tubulin monomer and indirectly by interacting with tubulin contacting regions of Ska1.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Juan Zou  

LAB HEAD: Prof. Juri Rappsilber

PROVIDER: PXD004952 | Pride | 2016-10-03

REPOSITORIES: Pride